Russia's defence ministry said at least 40 drones were shot down over the Moscow region, which along with the city itself has a population of more than 22 million.
The extent of the damage was not immediately clear but flights were diverted from at all of Moscow main airports.
Russia invaded Ukraine in February 2022 and currently controls a little under one fifth of Ukrainian territory.
Russia has pummelled its smaller neighbour with missiles and drones, recently targeting its energy sector. Ukraine this year sought to knock out Russian oil refineries and oil terminals with drones.
Ukrainian sea drones on Wednesday hit and disabled a tanker involved in trading Russian oil as it sailed through Ukraine's exclusive economic zone in the Black Sea to the Russian port of Novorossiysk, a Ukrainian official said.
War insurance costs for ships sailing to the Black Sea have spiked, with insurers reviewing policies daily as the conflict in Ukraine spills into sea lanes.
(Reporting by Reuters; Editing by Chris Reese and Stephen Coates)
A mural depicts a child with a dropper and a cat with an umbrella, that covers the child from a Russian missile on a wall of the Okhmadyt children's hospital in Kyiv, Ukraine, 10 December 2025, amid the ongoing Russian invasion. Ukrainian artist Andriy Yarmolenko created the mural. The Okhmadyt children's hospital was attacked by a Russian rocket during the massive shelling of Kyiv on 08 July 2024, when two people died, and 32 were injured, including the eight children who were hospitalized. EPA/SERGEY DOLZHENKO