Raids were conducted in 25 provinces, including Milan, Rome, Florence, Prato and Catania, anti-organised crime police official Andrea Olivadese said.
Police reported a further 31 people to judicial authorities without arresting them, and seized 550 grams (1.2 pounds) or around 5,500 doses of "shabu" crystal methamphetamines, and checked hundreds of shops and vehicles.
The gangs' crimes tend to exclusively target fellow Chinese, and, like traditional mafias, they "resort to intimidation and/or violence to achieve their goals" and seek to dominate the territory where they operate, police said.
The Chinese mob groups operate "with a deeply rooted concept of revenge that can take the form of a feud," they added.
In April, a senior figure in the Chinese underworld and a companion were shot dead in Rome, in what police suspected was part of a turf war within Chinese criminal networks in Italy.
Chinese gangs use the informal Hawala payment system to transfer money, and are "in constant dialogue" with other criminal organisations in Italy to share business and zones of influence, police said.
The gang members tend to hail from the same region in China and have a stronger foothold in parts of Italy with more Chinese residents, such as Tuscany, police noted.
Prato, a Tuscan city famous for its textile industry and its large Chinese community, has a long-running problem with labour exploitation, particularly among undocumented immigrants.
The arrests announced on Monday follow separate investigations exposing alleged worker abuse among Italian but Chinese-owned workshops in the supply chain of luxury brands such as Valentino, Giorgio Armani and Loro Piana.
(Reporting by Alvise Armellini; Editing by Bernadette Baum)

Police officers of the Italian Antimafia District Directorate, Division of Palermo, take part in a police operation in Palermo, Sicily, Italy, 11 February 2025. During an anti-mafia operation on 11 February, Italian Police arrested 181 suspected members of Cosa Nostra. EPA/IGOR PETYX