Some 450,0000 people are without shelter after 90 displacement camps were destroyed, Judith Suminwa Tuluka added.
The M23's advance is the gravest escalation in more than a decade of the long-running conflict in eastern Congo.
Rwanda rejects allegations from Congo, the United Nations and Western powers that it supports M23 with arms and troops.
The prime minister urged the world to act and to impose "dissuasive sanctions" amid mass displacements and summary executions.
"It is impossible to describe the screams and cries of millions of victims of this conflict", she added.
In the opening remarks at the 58th UN Human Rights Council in Geneva, UN chief Antonio Guterres said that human rights around the world are being "suffocated" and referred to horrifying human rights abuses in the Democratic Republic of Congo.
(Reporting by Olivia Le Poidevin, Editing by Miranda Murray)

Supporters of the M23 armed group march to reject the international community's involvement in the crisis between Rwanda and DR Congo, in Bukavu, South Kivu, Democratic Republic of the Congo (DR Congo), 22 February 2025. The M23 armed group seized Goma and Bukavu, two major cities in eastern DR Congo. United Nations officials in Africa warned during a UN Security Council on 19 February, that the offensive of the M23 in mineral-rich eastern Congo threatens peace in the wider region. EPA-EFE/MARIE JEANNE MUNYERENKANA
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