Since the Omicron variant of the coronavirus drove up infections to record highs in January the caseload has receded sharply and Covid-19 patients now account for just 3.5% of hospital occupation.
She said advisers have recommended lifting the obligation after the Easter long weekend.
Spain stopped mandatory outdoor mask use in early February but a significant number of Spaniards still choose to wear one in crowded areas. "A recommendation to wear masks responsibly will be issued when there are gatherings of people," she said.
On Tuesday, Spain's two week Covid-19 infection rate among over 60-year olds - the only age group for which the government publishes data - stood at 426 cases per 100,000 people, roughly the same as a month earlier.
(Reporting by Nathan Allen and Emma Pinedo, Editing by Inti Landauro, Kirsten Donovan)

A child hugs clown Aspirino before receiving the Covid-19 vaccine at a medical center in Mallorca, Balearic Islands, Spain, 22 January 2021 (issued on 23 January). Clowns of the non-profit medical association Medical Smile accompanied the children who got the vaccine this weekend. EPA-EFE/CATI CLADERA