The fire broke out in the 40-year-old building in Kaohsiung's Yancheng district in the early hours of the morning and was extinguished around dawn.
The Kaohsiung fire department said in a statement that after completing a search of the building they were able to confirm 46 deaths.
Mayor Chen Chi-mai said the building was partly abandoned, having previously been host to restaurants, karaoke lounges and a cinema.
The government is investigating the cause including whether arson was to blame. (Reporting by Ben Blanchard Editing by Peter Graff)

Banners showing Taiwan's President Tsai Ing-wen are on display near Tsai's campaign rally in Taipei, Taiwan, 17 November 2019. Tsai, from the pro-independence ruling party DPP, is seeking re-election on 11 January 2020. EPA-EFE/DAVID CHANG
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