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Global Virus Update: WHO advisers warn against extending vaccine dose intervals

Global Virus Update: WHO advisers warn against extending vaccine dose intervals
Experts advising the World Health Organisation on vaccine policies recommended against spreading the interval between two vaccine doses beyond 28 days, following a move by the UK to extend the period between shots to as much as 12 weeks in an effort to maximise coverage. (Photo: Rawpixel)

The US Food and Drug Administration urged that vaccines be given according to how they were authorised, in a rebuke to officials attempting to alter the timing and dosage of shots. Experts advising the World Health Organisation recommended against extending the interval between two doses, a plan under consideration in the UK

Pfizer backs two-dose shot schedule as UK spaces out shots

The European Union is negotiating with Pfizer Inc and BioNTech SE on a deal that could double its supply of the companies’ vaccine, people familiar with the talks said, as leaders across the region face questions over the pace of Covid-19 immunisations.

Key Developments:

  • Global Tracker: Cases pass 85.6 million; deaths exceed 1.85 million
  • Vaccine Tracker: More than 13 million shots given worldwide
  • US Hot Spots: Spike in South dwarfs earlier regional outbreaks
  • Video: US needs private-public vaccine plan, Johns Hopkins says
  • US risks years of higher mortality on Covid’s economic fallout
  • Why the UK’s mutated coronavirus is fanning worries: QuickTake

Subscribe to a daily update on the virus from Bloomberg’s Prognosis team here. Click CVID on the terminal for global data on coronavirus cases and deaths.

Johnson Says 1 in 50 in England Has Covid 

One person in every 50 now has coronavirus in England, the British government said, as medics raced to vaccinate millions of people against the disease.

Prime Minister Boris Johnson said 23% of all over-80s in England have now been given a dose of a Covid-19 vaccine, meaning some of the most vulnerable patients are getting the protection they need.

More than one million people in the country are infected, while in London one in 30 people are infected.

Indian vaccine hesitancy high even after approvals 

A survey of Indian citizens conducted after their country granted emergency approval to two coronavirus vaccines over the weekend found that 69% remained hesitant around getting Covid-19 jabs and wouldn’t rush to get them immediately — the same level as last month before the regulatory nod.

Poor communication in India has “led to a level of distrust building amongst citizens,” said LocalCircles, a New Delhi-based pollster that received 8,723 responses to a question about vaccine hesitancy. Many Indians don’t believe enough information is “available when it comes to vaccine side-effects, efficacy, etc from trials, which combined with declining case loads in India are top reasons why people are becoming hesitant.”

WHO advisers warn against extending dose interval 

Experts advising the World Health Organisation on vaccine policies recommended against spreading the interval between two doses beyond 28 days, following a move by the UK to extend the period between shots to as much as 12 weeks in an effort to maximise coverage.

Countries facing “exceptional circumstances of vaccine supply constraints” can delay administration of the second dose of two-shot vaccines for a few weeks, according to a statement from Alejandro Cravioto, chairman of the Strategic Advisory Group of Experts on Immunisation, but data on safety and efficacy after only one dose is lacking.

Arizona sees record deaths 

Arizona on Tuesday reported 253 deaths from Covid-19, a record for the state that brought its total tally during the pandemic to 9,317. The latest number may reflect a backlog of cases: Arizona reported just three deaths in the previous two days.

China’s Dalian city asks people in high-risk areas not to leave

China’s Dalian city announced that people in mid-to-high Covid-19 risk areas shouldn’t leave the city, and those in lower-risk areas have to provide a negative Covid test proof from the past three days if they need to depart, according to a statement from the city.

Separately, Shijiazhuang city, which reported 30 asymptomatic Covid-19 cases on 4 January, will suspend in-person classes at primary schools, middle schools and kindergartens, according to the city’s education bureau.

NY to ask cops, unions to help with vaccinations 

New York Governor Andrew Cuomo said he will ask police departments, fire departments and transit workers to organise their own distribution and vaccination systems.

“They have their own employees who can do the vaccines,” the governor said at a briefing on Tuesday. “To the extent we can have the essential workers use their own employees or their own health-system provider to do their own vaccines, that removes a burden from the retail system if you will, it removes them from the hospital system.”

Larger teachers unions, police departments and the Fire Department of New York could run their own vaccine programmes to alleviate the burden on systems dealing with the general public, he said. If they don’t have capacity, that’s fine, he said.

Cuomo also expressed concern about the variant of the virus first detected in England. “The UK strain is highly problematic and it could be a game-changer,” he said.

The governor called for the federal government to mandate testing for people flying in from other countries. “Not a travel ban, just mandatory testing. We have gone through this,” he said.

New Jersey records most deaths since May 

New Jersey reported 138 deaths, the most since May, and 5,400 new cases, Governor Phil Murphy said at an event in Iselin. Positive test results were more than double the number reported on Monday. “It gets worse before it gets better,” Murphy said of the pandemic.

Hospitals reported 3,702 people under Covid-19 treatment, and that figure has been mostly steady. But the number of intensive-care patients ticked up slightly, to 679, after dropping for six consecutive days.

The positivity rate was 15% as of 1 January, but Murphy cautioned that the figure may be unusually high because people tested on the holiday were likely to be experiencing symptoms.

UK reports record cases

The UK reported 60,916 new coronavirus cases on Tuesday, the most on record since the pandemic began. The country also reported 830 deaths, compared with a seven-day average of 611.

NYC mayor rips Cuomo’s hospital fine threat

New York City Mayor Bill de Blasio pushed back against Governor Andrew Cuomo’s threat to levy fines on hospitals that don’t administer vaccines quickly enough.

“Why don’t we stop talking about fines and start talking about the freedom to vaccinate?” de Blasio said during a Tuesday briefing.

New York City has administered only about 119,000 doses out of the 480,550 vaccines delivered. The city began inoculations in mid-December. “I take full responsibility” for speeding up the vaccinations, the mayor said.

Mitchell Katz, president of the city Health & Hospitals system, said everyone in all 11 public hospitals involved in direct patient care has been vaccinated in the past three weeks. His next goal is to vaccinate all staff, he said.

New York City’s Covid-19 infection data trended lower last weekend, with the seven-day average of new cases dropping to 4,064 as of Sunday, from 4,402 the previous day, and hospitalisations for that day totalling 210, just 10 above the public health safety threshold, after hitting a two-week high of 243 on 28 December.

Citywide tests had a 9.03% positivity rate over a two-week average as of Sunday, down from 9.22%. The rate of hospitalisation in the population stood at 4.07 per 100,000 for the second consecutive day.

Germany restricts movement 

Germany extended its lockdown and tightened restrictions as pressure mounts on Chancellor Angela Merkel’s government to contain the coronavirus spread and speed up vaccinations.

Merkel and state leaders agreed on Tuesday to limit non-essential travel to 15km for people living in areas with more than 200 cases per 100,000 people, according to a person familiar with the discussions.

Denmark on maximum alert amid variant concerns 

Denmark raised its Covid-19 alert level to the maximum and introduced fresh restrictions amid concerns over the more transmissible variant of the virus found in Britain.

The Nordic country’s alert level was moved up to five from four, signalling that contagion levels risk overwhelming the health service. While the number of new cases has fallen from its December peak, health officials say the presence of the British mutation on Danish territory could extend the state of emergency further.

Dutch to start immunisations, last in EU

The Netherlands will start its vaccination programme on Wednesday, giving the first shot to a nursing home employee. The start was moved forward by two days, but the country is still the last EU member to begin immunisations. Prime Minister Mark Rutte acknowledged his government should have been better prepared.

The country saw a decline in new cases in the past seven days, even as the number of deaths and of patients admitted to intensive care units climbed, health agency RIVM reported on Tuesday. Overall, RIVM concluded that “convincing effects” of the latest lockdown have not yet been achieved.

Ireland may toughen restrictions, PM says

The closure of construction sites and manufacturing operations is “on the agenda” for a decision by the government in coming days, Irish Prime Minister Micheal Martin said in an interview with RTE.

Schools may also stay closed in January as new infections hit records after spiralling out of control over the past month, he said. Martin said curbs are likely to remain in place until a substantial share of the population is vaccinated. Some 35,000 vaccinations will be given this month, he said.

Ireland reported “a considerable surge” in cases and hospitalisations on Tuesday. Local media reported that 25% of new cases were linked to the more contagious variant of the virus first detected in England.

France finds UK Covid variant in Paris region 

The more transmissible Covid variant discovered in the UK has been found in a patient in the Paris region, Paris hospitals head Martin Hirsch said on France 2 TV. Health authorities have completed contact tracing on the patient and the case “is under control,” Hirsch said.

Hirsch expects Paris region hospitals and nursing homes to vaccinate more than 10,000 staff and residents this week. French officials have come under fire for lagging behind other countries in rolling out vaccines. “For the next three weeks, we have the locations, we have the people, we have the doses, and we’re pressing ahead,” Hirsch said.

EU Seeks more Pfizer-BioNTech doses

The EU is negotiating a new contract that would include 100 million doses of the Pfizer-BioNTech vaccine, as well as an option for as many as 200 million more, people familiar with the matter said. Governments across the EU face scrutiny over the slow pace of their vaccine rollouts, and shots from other drugmakers such as AstraZeneca Plc won’t be available for weeks at the earliest.

Iran fatalities lowest since June 

Iran recorded 98 deaths in the past 24 hours, the lowest daily figure since June 18, and 6,113 new coronavirus cases. In all, the country has reported 1,255,620 infections and 55,748 deaths since the onset of the pandemic. Also on Tuesday, Health Minister Saeed Namaki said Iran had reported its first case of the new variant in a patient who had returned from the UK

Germany considers tighter curbs

Germany may need to tighten lockdown restrictions as well as extend existing curbs as officials struggle to distribute a vaccine fast enough to stem the pandemic.

Regional leaders lobbied in favour of tougher curbs ahead of talks on Tuesday with Chancellor Angela Merkel to decide the next steps in fighting the disease. Merkel and the 16 state premiers will consult by video conference amid general agreement that the closing of non-essential stores, restaurants and leisure facilities in December needs to be extended beyond 10 January.

Officials have yet to find a consensus on whether to open shuttered schools after the holidays and are discussing a chancellery proposal to limit how far people living in areas with high infection rates can move from their homes, local media reported. DM

— With assistance by Mark Schoifet, Dara Doyle, Joost Akkermans, Ilya Arkhipov, Iain Rogers, Rudy Ruitenberg, Zoltan Simon, John Follain, Naomi Kresge, Arys Aditya, Patrick Winters, Henry Goldman, Shelly Banjo, Elise Young, Keshia Clukey, Flynn McRoberts and Chris Kay.

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  • Caroline White says:

    The UK govt isn’t considering a longer interval between the two Covid 19 vaccine shots; it has decided to extend the iinterval from 3 weeks to 12 weeks, based on no scientific evidence. As someone in their seventies, living in London, this is a worrying development. The brilliant Scottish leader, Nicola Sturgeon has called for “grown ups” to make the decisions about Cotonavirus, rather than the “juvenile” Prime Minister, Boris Johnson.

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