Seven near-simultaneous explosions targeted bus stations, hospitals and other civilian sites in the seaside cities of Jableh and Tartus, which until now had been relatively insulated from Syria’s five-year war.

The attacks on strongholds of President Bashar al-Assad’s regime came as IS faces mounting pressure in Syria and neighbouring Iraq, where a major offensive to retake the jihadist-held city of Fallujah is underway.

One hundred people were killed in Jableh and another 48 in Tartus to the south, including children, said the Syrian Observatory for Human Rights monitor.

Observatory head Rami Abdel Rahman said they were “without a doubt the deadliest attacks” on the two cities since the start of the war.

IS claimed the blasts in a statement, saying they were in retaliation for Syrian regime and Russian air strikes against the jihadists and vowed to carry out “more devastating and bitter attacks”.

IS is not known to have a presence in Syria’s coastal provinces, where its jihadist rival, the Al-Qaeda-affiliated Al-Nusra Front, is much more prominent.

But IS, notorious for using deadly sleeper cells to attack its enemies, suggested the creation of a “wilayat al-Sahel” or Islamic province for the coastal area.

“I’m shocked, this is the first time I hear sounds like this,” said Mohsen Zayyoud, a 22-year-old student in Jableh.

– ‘First time we see dead people’ -In Tartus a 42-year-old bank employee was just as stunned.

“It’s the first time we hear explosions in Tartus, and the first time we see dead people or body parts here,” said Shady Osman.

Jableh lies in Latakia province, while Tartus is the capital of the adjacent governorate of the same name.

Both have remained relatively secure even as the war has raged in Latakia province’s rural northeast and throughout the country.

The early morning attacks began at a bus station in Tartus, where regime ally Russia has long maintained a naval facility.

The Observatory said a car bomb exploded and as people began to flock to the site two suicide bombers detonated explosive belts.

A police source in the city confirmed a car bomb had hit the entrance to the station and two suicide bombers attacked inside, while footage from state television showed charred mini-buses and other vehicles ablaze.

Around 15 minutes after the Tartus blasts, four explosions rocked Jableh further north.

– Hospital blast -The Observatory said a car bomb and three suicide attackers targeted the bus station, a hospital, and a power station.

One attacker detonated explosives inside the emergency room of the state-run hospital after carrying victims of the first attack there, and a police officer said a car bomb also targeted the Asaad hospital in the city.

The attacks drew condemnation from around the world, while Human Rights Watch warned that targeting civilians “would appear to constitute war crimes”.

UN chief Ban Ki-moon denounced the “terrorist attacks” while France called the bombing heinous.

US Secretary of State John Kerry spoke to Russian counterpart Sergei Lavrov by phone and urged him to press the Syrian regime to halt its attacks on Aleppo in the north and Daraya near Damascus.

State Department spokesman Mark Toner accused the Assad regime of using air strikes and attacks on civilians to gain tactical advantage and said Russia “has a special responsibility” to rein in Syrian government forces.

Toner added that Washington is looking to Russia to provide the pressure needed to get the regime “to reconsider the fact that if this keeps up, we may be looking at a complete breakdown of the cessation”, referring to a faltering truce agreed in February.

The Kremlin said the attacks “demonstrate yet again how fragile the situation is in Syria and the need to take energetic measures to relaunch peace talks”.

World powers have struggled to rekindle UN-brokered peace negotiations which fizzled in April when Syria’s opposition walked away in frustration at stalling progress on the country’s dire humanitarian situation.

Syria’s conflict has evolved from a popular uprising to a multi-faceted war that has killed more than 270,000 people and displaced millions.

IS has claimed deadly attacks in the West and throughout the Middle East, including twin bombings on military forces in Yemen’s second city of Aden on Monday that killed at least 41 people.

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